Prabhupada, February 28, 1975, Atlanta: How it is scientific? Life is already there. Not that the life production is depending on your future scientific research. The life is already going there, hundreds and thousands and millions. You say that you do not know. Why you are claiming that “In future we shall know”? There is no need of your knowing, it is already going on. You do not know. That is your position. And still, you are declaring yourself as scientist. You are misleading. You can make a fool’s paradise, that is another thing. But you do not know at the present moment, but the things are going on. Life is being produced without your knowledge. So you admit that you have no knowledge. And without having knowledge, you are declaring yourself as scientist—how much cheating it is. It is not that it is depending on your future knowledge. It is already going on. Life is being produced. So if you think that in future, by chemical combination you will produce life, so that chemical composition is already there, going on. So you have to find out who is that scientist, not that chemical composition. Who is that scientist who is producing so many lives and chemicals? That is real intelligence.
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Major Step Forward In Cell Reprogramming, Researchers Report
ScienceDaily (Oct. 10, 2009) — A team of Harvard Stem Cell Institute (HSCI) researchers has made a major advance toward producing induced pluripotent stem cells, or iPS cells, that are safe enough to use in treating diseases in patients.
“This demonstrates that we’re halfway home, and remarkably we got halfway home with just one chemical,” said Kevin Eggan, an HSCI principal faculty member who is the senior author of the paper being published online today by the journal Cell Stem Cell.
“There are four genes that do this, and with just one chemical we replaced half the genes,” said Eggan, who is also an assistant professor in Harvard’s Department of Stem Cell and Regenerative Biology. “The one chemical replaces those two genes in different ways at different times in the experiment. The experiments we
performed not only led to discovery of the chemical, but they also explained how it works,” he said.
The chemical that the team used is a small molecule that members named RepSox in honor of another Boston team. It replaces Sox2 and cMyc, two of the four genes currently being used to reprogram adult skin cells into an embryonic-like state. Because cMyc is a tumor promoter and iPS cells created using it could never be used to treat patients, researchers have been looking for ways to turn back the cellular clock without the use of genes.
Lee Rubin, director of translational medicine at HSCI and the other senior author on the research team, said that “our goals were to try to as discretely and specifically as possible guide the cells through the deprogramming process” from the adult state to the embryonic-like state.
Finding a way to produce safe iPS cells that are the biological equivalent of embryonic stem cells is especially important because the cells can then be created from the cells of individual patients for transplantation into those patients. Thus, a patient with Parkinson’s disease might be treated with neurons created from his own cells, theoretically eliminating the need for immunosuppressive drugs, or the possibility of rejection of the transplanted cells. Similarly, patient-specific iPS cells could be used to create muscle for damaged hearts, or other individualized treatments.
Additionally, iPS cells derived from the skin cells of patients with specific diseases can be used as a source of differentiated cells to study those disease processes in a laboratory dish, and manipulated to find better drug targets and more effective therapeutics.
“This discovery is exciting because it demonstrates the feasibility of using chemicals to make safer patient-specific stem cells for transplantation medicine,” said Justin K. Ichida, a postdoctoral fellow in Eggan’s lab and the first author on the study. “One of the most important things we learned from this study is that, with respect to molecular pathways, there may be several ways to convert one type of cell into another. By using a nonbiased chemical screening approach, we uncovered a previously unknown way to make stem cells. The big challenge over the next decade will be to figure out how to make the right cells for disease treatment. This approach will be important for achieving that goal.”
Other co-first authors on the study are Joel Blanchard, Kelvin Lam, and Esther Y. Son. Additional contributors include Julia E. Chung, Dieter Egli, Kyle M. Loh, Ava C. Carter, Francesco P. Di Gorgio, Kathryn Koszak, Danwei Huangfu, Hidenori Akutsu, and David R. Liu.
The study was funded in part by the Harvard Stem Cell Institute, the
Stowers Medical Institute, the Howard Hughes Medical Institute, and the New York Stem Cell Foundation
Curious how hundreds of biophysicists in the US have died or disappeared under unusual circumstances in the last couple of years. Their names and details are described elaborately on the net, so it is more than just a rumor. How is it that those of this speciality are suddenly disappearing?
I recall similar research being splashed all over the front pages, for all of about eight hours before being removed with no explanation, which articles on such as the major Canadian newsources, saying that a long established team of biophysicists have found a process to REVERSE aging, not just slow or stop it in limited circumstances! The geneticists claimed to have turned old mice into young mice, similarly to have regrown old heart and other organs into young ones. They showed the experimental creatures, organs, and outlined the main descriptive data of their work. This was explained to be the result of decades of research.
But the world-shaking news was there on mainstream media for a few hours only, and shortly thereafter dissappeard and could not be found; one cannot even find an obscure reference to it now, on the net.
One is tempted to speculate; age reversal, missing scientists, hugely expensive research, overpopulation, over 1500 underground survival bunkers built in the last three years by govenmnts all over the world; is it just me, or do these add up to dangerous demonic numbers? HKHR